Bioinformatics and variability in drug response: a protein structural perspective

Bioinformatics and variability in drug response: a protein structural perspective.

Marketed drugs frequently perform worse in clinical practice than in the clinical trials on which their approval is based. Many therapeutic compounds are ineffective for a large subpopulation of patients to whom they are prescribed; worse, a significant fraction of patients experience adverse effects more severe than anticipated. The unacceptable risk-benefit profile for many drugs mandates a p...

features of short story in translated and non-translated literature: a polysystemic perspective

ترجمه متون ادبی در دنیای امروز از اهمیت ویژه ای برخوردار است. فرهنگ های مختلف با استفاده از متون ادبی ملل و فرهنگ های دیگر سعی در غنی کردن فرهنگ و ادبیات کشور خود دارند. کشور ما نیز از این قاعده مستثنی نیست. در ایران، ترجمه متون ادبی اروپائی که با دوران مشروطه ایرانی آغاز می شود موجب تغییرات اساسی در فرهنگ، شیوه زندگی و تفکر ایرانیان شده است. در این دوران نه تنها در امورات سیاسی و فکری کشور تغی...

Structural interaction between drug - DNA and protein- A novel approach for bioinformatics in medicine

Drug like methotrexate were used in the present study because of dual importance, both for clinicians as well as an interest of basic scientists. Methotrexate, an antineoplastic agent is used for malignant as well as non malignant conditions and become teratogenic & mutagenic in nature. They prevent cell proliferation by incorporated into DNA during the "S"phase of the cellcycle and inhibit rap...

Structural Bioinformatics for Protein Engineering

Accelerated Structural Bioinformatics for Drug Discovery 5

Computer-aided design is one of the critical components of modern drug discovery. Drug development is routinely streamlined using computational approaches to improve hit identification and lead selection, to enhance bioavailability, and to reduce toxicity. In the last decade, a mounting body of genomic knowledge has been accumulated due to advancements in genome-sequencing technologies, present...